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Book
Onze genen : handboek menselijke erfelijkheid
Authors: ---
ISBN: 9789033485565 Year: 2011 Publisher: Leuven Acco

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Abstract

Er gaat vrijwel geen dag voorbij zonder dat er sprake is van nieuwe ontdekkingen op het gebied van de erfelijkheid. Ook het gebruik van technieken die gebaseerd zijn op de kennis van de erfelijke code neemt hand over hand toe. Denk aan de genetische vingerafdrukken die steeds vaker gebruikt worden bij het opsporen van potentiële daders, het vroegtijdig diagnosticeren van mogelijke afwijkingen of zelfs het corrigeren ervan door gebruikmaking van genetische manipulatietechnieken.Om al die redenen is een basiskennis van hoe de erfelijkheid werkt en hoe ze aangewend kan worden een vereiste om mee te kunnen denken en te beslissen in de hedendaagse samenleving.Dat is wat dit boek beoogt te brengen. Onze genen zet de huidige kennis over de menselijke erfelijkheid helder uiteen. Alle belangrijke thema's komen erin aan bod: zowel de elementaire inzichten betreffende de bouw van het erfelijke materiaal en de manier waarop het omgezet wordt in lichaamseigenschappen, als recentere informatie over het ontstaan van specifieke afwijkingen, de mogelijkheden en beperkingen van erfelijkheidsdiagnose en van stamcel- en gentherapie, tot en met de nieuwe ontwikkelingen binnen het domein van de epigenetica. Voorts wordt ook aandacht besteed aan enkele aanverwante thema's, zoals het ontstaan van kanker en de gedragsgenetica.Het boek richt zich in de eerste plaats tot studenten binnen de paramedische en de psychosociale en pedagogische opleidingen. Maar doordat de tekst zo is opgesteld dat er geen specifieke voorkennis vereist wordt, kunnen ook andere geïnteresseerden er heel wat nuttige inzichten uit halen.


Book
Phosphodiesterases as Drug Targets
Authors: --- ---
ISBN: 9783642179693 9783642179686 3642179681 364217969X Year: 2011 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Abstract

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

Keywords

Chemical structure --- cytologie --- Clinical chemistry --- biochemie --- Histology. Cytology --- moleculaire structuur --- General biochemistry --- biosynthese --- genetische manipulatie --- massaspectrometrie --- toxicologie --- polypeptiden --- aminozuren --- eiwitten --- Pharmacology. Therapy --- medische chemie --- Organic spectroscopy --- Cyclic nucleotide phosphodiesterases. --- Drug targeting. --- Toxicology. --- Biochemistry. --- Enzymes. --- Post-translational modification . --- Cell physiology. --- Pharmacology/Toxicology. --- Medicinal Chemistry. --- Protein Structure. --- Enzymology. --- Posttranslational Modification. --- Cell Physiology. --- Cell function --- Cytology --- Physiology --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- Genetic translation --- Proteins --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Enzymology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Synthesis --- Composition --- Toxicology --- Pharmacology. --- Medicinal chemistry. --- Proteins . --- Posttranslational modification. --- Biochemistry --- Enzymes --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect


Book
Histone Deacetylases: the Biology and Clinical Implication
Authors: ---
ISBN: 9783642216312 9783642216305 3642216307 9786613365934 1283365936 3642216315 Year: 2011 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Abstract

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Keywords

Chemical structure --- protein-engineering --- biosynthese --- biochemie --- toxicologie --- General biochemistry --- massaspectrometrie --- genetische manipulatie --- Human biochemistry --- medische biochemie --- medische laboratoriumtechnologie --- polypeptiden --- aminozuren --- eiwitten --- Pharmacology. Therapy --- Semiology. Diagnosis. Symptomatology --- Organic spectroscopy --- Histone Deacetylases --- Histone Deacetylase Inhibitors. --- Neoplasms --- Sirtuins --- Histone deacetylase. --- Histone désacétylase --- physiology. --- drug therapy. --- EPUB-LIV-FT LIVBIOLO LIVBIOMO LIVMEDEC SPRINGER-B --- Physiology. --- Drug therapy. --- Toxicology. --- Medicine. --- Post-translational modification . --- Biochemistry. --- Medical laboratories. --- Medical genetics. --- Pharmacology/Toxicology. --- Biomedicine general. --- Posttranslational Modification. --- Protein Science. --- Laboratory Medicine. --- Gene Function. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- Genetic translation --- Proteins --- Health Workforce --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Genetic aspects --- Composition --- Synthesis --- Toxicology --- Pharmacology. --- Posttranslational modification. --- Proteins . --- Laboratory medicine. --- Biomedicine, general. --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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